TO ESTIMATE THE URIC ACID LEVELS IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME (PCOS)

Background- Pcos is most common endocrine disorder now a day in females, it appears due to abnormalities in metabolism of androgen and estrogen. It is not only an endocrine disorder but also a metabolic, hormonal and psychological disorder. It causes infertility, distress, hirsutism, irregular menstrual, or biochemical findings. This study aims to evaluate the biochemical parameter, Uric Acid in PCOS women and to assess its effect in these patients and to compare the assessed parameter with that of normal controls.

Methods - After applying inclusion and exclusion criteria, blood samples are collected from 50 menopausal women diagnosed to have PCOS by ultrasound and 50 healthy controls (Pre-Menopausal Women) aged 18-40 years. Serum Uric Acid was done in both PCOS patients and controls. The correlation between the biochemical parameters are studied in the PCOS group.

Results- There was a significant increase in serum uric acid levels in PCOS patients as compared to controls. So, uric acid in PCOS cases as an indicators of early metabolic changes that can be used to diagnose PCOS women at risk of cardio metabolic syndrome. And also it showed that, increased uric acid levels in PCOS patients as compared to controls which were statistically significant.

Conclusion- The findings of this study confirms the Uric acid in PCOS and may help to identify women with PCOS at risk of cardio metabolic syndrome, there by confirming the association between PCOS and cardiovascular risk factors.