SERUM LEPTIN AND ADIPONECTIN IN INDIAN FEMALE POPULATION WITH THYROID DYSFUNCTION

Thyroid dysfunction is associated with metabolic changes that affect mass and adipocyte function. Adipose tissue is confirmed to be a gland that secretes several molecules with multiple metabolic functions. Both adipokines (Leptin and adiponectin) and thyroid hormone may be affected by energy balance and body weight. A relationship between these 2 endocrine systems seems intuitive.. In recent years an extensive research is under way to explore the mutual roles of different adipokines and thyroid hormones. The aim of this study was to evaluate the relationships between thyroid status and circulating levels of the two adipose tissue hormones in Indian female population. We studied 38 female patients with hyperthyroidism, 38 female patients with hypothyroidism and 38 euthyroid female subjects, all matched by age and body mass index (BMI). Serum concentrations of thyroxine, triiodothyronine, TSH, leptin and adiponectin were assessed. The study showed that serum adiponectin is statistically increased in hyperthyroid females while serum leptin concentration was significantly increased in hypothyroid females. We concluded that changes associated with thyroid dysfunction in Indian female population are related to variations in serum levels of adiponectin and leptin independent of BMI.