THE POSSIBLE EFFECTS OF THYMOQUINONE AND PARSLEY IN EXPERIMENTALLY INDUCED RENAL INJURY ASSOCIATED WITH GASTRIC ULCER IN RATS

Acute renal failure (ARF) is still associated with high in-hospital mortality, may be due to acute gastrointestinal hemorrhage (AGIH), especially in the upper gastrointestinal tract. Gastric ulcers and/or erosions are the most common source of AGIH. Objective: This study investigates the effect of thymoquinone (TQ) and parsley in experimentally induced renal injury associated with gastric ulcer. Materials and methods: A total of 80 rats were randomly classified into four experimental groups: Group 1 (normal group), Group 2 (Gly & ethanol) for induction of renal injury and ulcer, group 3 and 4 receive thymoquinone (10 mg/kg) and parsley (600 mg/kg) respectively for 14 days. The serum levels of creatinine, blood urea nitrogen (BUN) and potassium were measured. Malodialdehyde (TBARs) and reduced glutathione (GSH), myeloperoxidase (MPO), tumour necrosis factor alpha (TNF-?), caspase 3 activity and superoxide dismutase (SOD) activities were measured in stomach and renal tissue, also gastric mucosal lesions and ulcer index were assessed. Renal and stomach histopathological examination were carried out. Results: Glycerol and ethanol caused renal and gastric injury noted by increased level of creatinine, BUN, TBARs, MPO, TNF?, caspase 3 activity and decrease GSH content, SOD activity, Histopathological examination revealed definite alterations. Thymoquinone and parsley significantly reduced serum creatinine, BUN, potassium, TBARs, MPO, TNF?, caspase 3 activity, gastric ulcer, gastric index as well as histopathlogical examination and significantly increased GSH content and SOD activity. Conclusion: based on our study it could be concluded that TQ and parsley have protective effects in renal injury associated with gastric ulcer.