IMPACT OF DOXORUBICIN AND VITAMIN E, A SEPARATELY AND IN COMBINATION ON SELECTED ENZYMATIC ACTIVITY LEVELS INVOLVED IN THE ENERGY METABOLISM IN THE MAJOR TISSUES OF ALBINO RAT
- Department of Zoology, SV University Tirupati, A.P, India.
- Department of Zoology, PS Govt. Degree College, Penukonda, Ananthapuram Dt, A.P.
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Doxorubicin (DOX) is an anthracyclin antibiotic with broad spectrum of antitumour activity. Use of this agent has been shown to cytotoxicity. The effect of 20 mg per Kg weight of Dox and 100 mg per Kg weight of vitamin E and 50 IU per Kg weight of Vitamin A separately and in combination treated rat tissues for 10 weeks period (weekly doses). The state of rat tissues based on energy metabolic enzymes like ATPase and cytochrome-c-oxidase activity levels are reported. The data indicated decreased levels of ATPase and cytochrome-c-oxidase under Dox stress were observed. Above two Dox altered rat tissues energy metabolic enzymes to be neutralized by in administration of Dox plus vitamin E and Dox plus vitamin A. From the result it is reported that Dox impair the overall energy metabolism of rat tissues and that antioxidants like vitamin E and A by their antioxidant mechanism might be neutralize the Dox altered rat tissues like ATPase and cytochrome-c-oxidase activity levels in vivo.
[B Vijayudu, K Harish Babu, Y Venkatakrishnaiah and M Rajeswara Rao (2015); IMPACT OF DOXORUBICIN AND VITAMIN E, A SEPARATELY AND IN COMBINATION ON SELECTED ENZYMATIC ACTIVITY LEVELS INVOLVED IN THE ENERGY METABOLISM IN THE MAJOR TISSUES OF ALBINO RAT Int. J. of Adv. Res. 3 (Jun). 481-486] (ISSN 2320-5407). www.journalijar.com
