Dynamics of milk leukocytes in response to the polysaccharide fraction of Tinospora cordifolia in bovine sub clinical mastitis

Somatic cell count (SCC), phagocytic activity and percent neutrophil and lymphocyte count in milk were evaluated after intramammary infusion of polysaccharide fraction of T cordifolia (PFTC) in bovine sub clinical mastitis (SCM). Intramammary infusion of PFTC treatment significantly reduced the SCC and neutrophil count, conversely to the above the phagocytic activity of milk polymorphonuclear cells (PMNs) and lymphocyte count enhanced (P<0.05). The results suggest that the PFTC possesses antiinflammatory and immunomodulatory properties. In the present study the biological activity of the PFTC at standardized dose against bovine sub clinical mastitis is reported for the first time.