Endothelial Nitric Oxide Synthase Gene Polymorphism (T-786C) and Cerebrovascular Storke with or without Smoking
- Molecular Genetics and Enzymology Department , Human Genetic Division, National Research Center, Cairo, Egypt.
- Medical Biochemistry Department , Shaqra University , Faculty of Medicine Dawadmi.
- Internal Medicine Departments, Sohag Faculty of Medicine, Sohag University Egypt.
- College of Applied Medical Sciences Dawadmi Shaqra University.
- Medical Biochemistry Department, Sohag Faculty of Medicine, Sohag University Egypt.
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Background: Cerebrovascular Stroke (CS) is the second common cause of death and major cause of disability throughout the world. CS mainly originates mainly from ischemic cause secondary to multifactorial disorder. Aim of the work: to determine the association of serum nitric oxide and T-786C polymorphism of eNOS in cerebrovascular stroke patients with or without smoking. Patients and Methods: A total forty two patients with cerebrovascular stroke (25 with and 17 without cigarette smoking). Patients with diabetes mellitus, renal disease, chronic obstructive pulmonary disease and hepatitis were excluded from the study group. Their age ranged between 45 to 60 years. Genotyping analysis was done by combination of techniques PCR and sequencing. Results and conclusions the presence of the eNOS mutant allele reduces endothelial production of NO and may predispose the patients carrying the mutant allele to cerebrovascular stroke.
[Ahmed I. Abd Elneam, Ahmed M. Boghdady, Ali I. Ali Abd Alrheam and Mohamed A. Taher (2015); Endothelial Nitric Oxide Synthase Gene Polymorphism (T-786C) and Cerebrovascular Storke with or without Smoking Int. J. of Adv. Res. 3 (Jun). 619-624] (ISSN 2320-5407). www.journalijar.com
