AETIOLOGICAL FACTORS FOR H.C.C- EXPERIENCE AT TERTIARY CARE CENTRE OF NORTHERN INDIA

Hepatocellular Carcinoma (HCC) is one of the most common malignant tumours in the world. It is a heterogeneous group of a tumour which varies in risk factor, genetic and epigenetic alteration event. The mortality rate due to it is increasing with time. The various risk factors include hepatitis B &C viruses, alcohol, metabolic syndrome including diabetes mellitus, chemicals, and inborn and acquired metabolic disease. HCC is closely associated with hepatitis B and C virus because liver injury caused by viral factor affects many cellular processes such as cell signalling, apoptosis, transcription, DNA repair which in turn induce important effects on cell survival, growth, transformation and maintenance. The molecular mechanisms of hepatocellular carcinogenesis vary depending on different factors thus leading to different mechanisms associated with these tumours. Our study shares the experience of various aetiological factorsresponsible for HCC at tertiary care centre of Northern India.