The relationship between CD40 gene polymorphism and acute coronary disease in diabetic and non diabetic patients
- Clinical Pathology Dept., Mansoura University, Egypt.
- Cardiology Dept., Dekernis Hospital, Egyptian Ministry of Health, Egypt.
- Faculty of Health Sciences, American University of Beirut, Lebanon.
- Anatomy Dept., Mansoura University, Egypt.
- Internal Medicine Dept., Mansoura University, Egypt
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Background: Genetic background of type 2 diabetes and CAD is still under investigations as an important player of differences in the clinical course of the disease. This study aimed to examine the association between CD40 gene polymorphism and coronary artery disease (CAD) in diabetic and non diabetic patients groups . Objective: To our current knowledge, no research had been conducted in Egypt to discuss the association between the single nucleotide polymorphism(SNP) and genetic susceptibility to ACS in the Egyptian population. In our study, we investigated the possible role of the polymorphism in the pathogenesis of ACS as a major complication of diabetes mellitus in the Egyptian population and the potential of using this polymorphism as a marker to identify high risk patients who would have adverse out comes and cardiac events. Methods: We randomly selected 135 myocardial infarction (MI) patients aged 35 to 65 years and 50 healthy age-matched controls from Mansoura University hospitals. Cases were further subdivided into two groups according to the presence or absence of DM. The gene polymorphism was detected by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) . Results: Analysis of the distribution of the CD40 gene polymorphism between patients and controls showed that C allele frequency was significantly higher than the control group. The C allele increased the risk of CAD about 1.8 times compared with the control group(p<0.05).There was no statistically significant difference of genotype or allele type distribution in non-diabetic coronary heart disease patients (p=0.502) and diabetic coronary heart disease patients (p=0.415). Conclusion: Our results suggests that there is an association between SNP (?1C/T) and acute myocardial syndromes that is independent of the presence of diabetes. We found that C allele frequency increased the risk of disruption of CAD .
[H. Mosaad, Narmin Saied, A. EL Said, M. Godah, D. Mahmoud, Ossama Fouda (2015); The relationship between CD40 gene polymorphism and acute coronary disease in diabetic and non diabetic patients Int. J. of Adv. Res. 3 (Jul). 944-951] (ISSN 2320-5407). www.journalijar.com
