NEUROENDOCRINE NEOPLASMOF THE SPHENOID: CASE REPORT AND LITERATUREREVIEW

Neuroendocrine tumors (NETs) of the sphenoidregion are extremely rare(1)and pose significant diagnostic and therapeutic challenges due to their aggressive potential and complexanatomical location. Wepresent a case of a 34-year-old male whoinitiallypresentedwith persistent headaches and subsequentlydevelopedcranial nerve involvement, leading to the diagnosis of a sphenoid neuroendocrine tumor with cavernous sinus invasion. Given the surgicalrisks, a conservative approachwithsomatostatinanalogtherapywaschosen, resulting in partial tumorresponse. However, disease progression occurredaftertreatment discontinuation. This case underscores the importance of long term follow up and the need for individualized treamentstrategies in managing base neuroendocrine tumors(2).