ROLE OF RADIO DIAGNOSIS IN EARLY DETECTION OF ALZHEIMERS DISEASE:A SYSTEMATIC REVIEW

Alzheimers disease (AD) represents the most prevalent form of dementia, affecting millions worldwide and posing significant public health challenges.Early detection remains critical for initiating timely interventions that may mitigatedisease progression, particularly during preclinical or mild cognitive impairment (MCI) stages. Radio diagnostic modalities, including Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Diffusion Tensor Imaging (DTI), and emerging techniques like arterial spin labeling (ASL), providen invasive tools to identify structural, functional, and molecular brain changes associated with AD. This systematic review synthesizes evidence from peer-reviewed literature to evaluate the role of these imaging modalities in early AD detection, emphasizing their diagnostic capabilities, clinical applications, and integration with other biomarkers.Following the PRISMA framework, the review identifies key modalities suchas structural MRI for detecting hippocampal atrophy, amyloid-PET for visualizing pathological protein aggregates, and functional MRI for assessing connectivity disruptions. The review also explores challenges in standardization, accessibility, and cost, alongside future directions involving artificial intelligence and novel imaging tracers.Comprehensive visual aids, including flowcharts and schematic diagrams, illustrate imaging workflows and diagnostic frameworks.