BREXPIPRAZOLE AUGMENTATION ON MIRTAZAPINE FOR TREATMENT-RESISTANT DEPRESSION IN AN ELDERLY PATIENT
Parinda Parikh
, Himani Suthar
, Parthiv Pansuriya
, Shauryakumar Singh
, Arnesh Shukla
, Aatish Bhatta
, Jeremy Kays
, Alisha Arul Alphonse
, Arushi Kaushik Chandra B.E
, Mahiya Buddhavarapu B.S
, Avinash Kesavarapu B.S
, Zoe Gellert B.S
and Mina Oza
- Department of Psychiatry, Weill Cornell Medical School, White Plains, USA.
- GMERS Medical College and Civil Hospital, Gandhinagar, India.
- Goverment Medical College Surat, India.
- Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
- St. Martinus University, Willemstad, Curacao.
- KIST Medical College and Teaching Hospital, Lalitpur, Nepal.
- Windsor University School of Medicine, St.Kitts, West Indies.
- St. Georges University, Grenada, West Indies.
- NYU Steinheart School of Culture, Education and Human Development, New York, USA.
- University of Pittsburgh, Pennsylvania, USA.
- Tulane University, New Orleans, USA.
- 2ND ARC Associates, White Plains, USA.
- Abstract
- Cite This Article as
- Corresponding Author
Treatment-resistant depression (TRD) poses a significant clinical challenge, particularly in elderly patients, due to age-related physiological changes, comorbidities, and reduced medication tolerability. TRD is generally defined as a major depressive disorder (MDD) that fails to respond to at least two adequate antidepressant trials. In this case, a 64-year-old male with no prior psychiatric history presented with a two-month history of depressive symptoms including insomnia, weight loss, paranoid delusions, and social withdrawal. Mirtazapine was initiated with partial improvement. Following the addition of brexpiprazole, the patient demonstrated marked clinical improvement in mood, motivation, and daily functioning.This case underscores the complexity of treating TRD in elderly patients and highlights the potential synergistic effect of combining mirtazapine with brexpiprazole, The pharmacological complementarity of these agents may enhance antidepressant efficacy while minimizing adverse effects in geriatric populations.
[Parinda Parikh, Himani Suthar, Parthiv Pansuriya, Shauryakumar Singh, Arnesh Shukla, Aatish Bhatta, Jeremy Kays, Alisha Arul Alphonse, Arushi Kaushik Chandra B.E, Mahiya Buddhavarapu B.S, Avinash Kesavarapu B.S, Zoe Gellert B.S and Mina Oza (2025); BREXPIPRAZOLE AUGMENTATION ON MIRTAZAPINE FOR TREATMENT-RESISTANT DEPRESSION IN AN ELDERLY PATIENT Int. J. of Adv. Res. (May). 1300-1303] (ISSN 2320-5407). www.journalijar.com
Department of Psychiatry, Weill Cornell Medical School,White Plains , USA
United States
