CONTINUOUS IMPROVEMENTS IN THE PRODUCT PORTFOLIO OF LIPOSOMAL IRONBY WBCIL TO OFFER ENHANCED NUTRACEUTICAL EFFICACY AND PUBLIC HEALTH SAFETY

Liposomal Iron is an advanced delivery system designed to address the limitations of traditional Iron supplements, including low bioavailability, gastrointestinal side effects, and oxidative instability. In our previous study, we established the basic nutraceutical potential of Liposomal Iron manufactured by West Bengal Chemical Industries Ltd., Kolkata, India (WBCIL). This article builds on that work using advanced analytical techniques to further characterize its physicochemical properties, structural interactions,and encapsulation efficiency. Advanced analyses using Dynamic Light Scattering (DLS), Zeta Potential Analysis, Fourier Transform Infrared (FTIR) Spectroscopy, Scanning Electron Microscopy (SEM), Energy Dispersive X ray Analysis (EDAX), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and mineral loading studies were employed to comprehensively characterize the Liposomal Iron formulation. The results demonstrated that Liposomal Iron exhibited a high encapsulation efficiency of 89%, nanoscale particle size of 153.8nm, and a zeta potential of 61.2mV, indicating excellent colloidal stability. FTIR confirmed strong interactions between Iron and phospholipid components, while SEM revealed well-defined, spherical Liposomes with no aggregation. EDAX analysis showed complete encapsulation of Iron with no surface exposure. Stability studies under thermal and accelerated conditions confirmed minimal leakage and consistent assay values over time. DSC and TGA analyses demonstrated enhanced thermal stability and delayed decomposition, while the mineral loading capacity was determined to be 0.71mg Iron/mg Liposomal material, indicating efficient Iron incorporation. These findings confirm that Liposomal Iron formulated by WBCIL is a stable, efficient, and advanced delivery system with strong potential for nutraceutical applications.