EVALUATION OF NEUTROPHIL-TO-LYMPHOCYTE AND PLATELET-TO-LYMPHOCYTE RATIOS AS BIOMARKERS OF DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS
- MD Medicine, Department of Medicine, PGIMS, Rohtak, Haryana.
- Senior Professor and Unit Head department of Medicine, PGIMS Rohtak, Haryana.
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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease in which accurate assessment of disease activity is essential for treatment decisions. Conventional indices such as DAS28 and CDAI are widely used but require joint counts and laboratory support. Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) has emerged as simple, inexpensive markers of systemic inflammation, but their role in monitoring RA remains underexplored.
Objective: To evaluate the relationship of NLR and PLR with RA disease activity and compare their correlation with validated composite indices.
Methods: In this prospective observational study, 100 RA patients fulfilling ACR/EULAR 2010 criteria were enrolled. Clinical disease activity was assessed using DAS28 and CDAI at baseline and after three months of treatment. Complete blood counts were performed, and NLR and PLR were calculated. Changes in indices were analyzed, and correlations between hematological ratios and disease activity were determined.
[Gurjinder, Harpreet Singh, Hemant Sharma, Mahima Khatkar, Ritu Sangwan and Pratibha Yonzone (2025); EVALUATION OF NEUTROPHIL-TO-LYMPHOCYTE AND PLATELET-TO-LYMPHOCYTE RATIOS AS BIOMARKERS OF DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS Int. J. of Adv. Res. (Oct). 60-68] (ISSN 2320-5407). www.journalijar.com
