GC MS BASED CHEMICAL PROFILING AND ANTIMICROBIAL ACTIVITY OF ZIZIPHUS JUJUBA SEED OIL

The growing problem of antimicrobial resistance has highlighted the urgent need for novel therapeutic agents. Medicinal plants and their bioactive components, particularly seed oils, have gained attention due to their rich chemical composition and diverse pharmacological activities. In this study, seed oil of Ziziphus jujuba was extracted and subjected to chemical profiling using gas chromatography mass spectrometry (GC MS), followed by evaluation of its antimicrobial potential. GC MS analysis identified 12 major components, with heptadecanoic acid methyl ester (51.77%), tetracosanoic acid methyl ester (8.70%), and hexadecanoic acid methyl ester (7.99%) as dominant constituents. The oil exhibited strong antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Candida albicans, but showed limited effectiveness against Pseudomonas aeruginosa. These findings suggest that Ziziphus jujuba seed oil is a promising source of bioactive compounds with potential applications as natural antimicrobial agents.