Wound dressing membranes based on chitosan: Preparation, characterization and biomedical evaluation
- Polymer Materials Research Department, Advanced Technologies and New Materials Research Institute, City of Scientific Research and Technological Applications, New Borg El-Arab City 21934, Alexandria, Egypt.
- Chemistry Department, Faculty of Science, University of Jeddah, Osfan, P. O. Box: 80203, Jeddah 21589, Saudi Arabia.
- Organic Chemistry Department, Faculty of Science, Ain-Shams University, Cairo, Egypt.
- Abstract
- Keywords
- Cite This Article as
- Corresponding Author
Chitosan based film for biomedical applications were prepared by casting and drying in presence of different amount of cinnamaldehyde. Chemical and physical studies were done for prepared membranes. Ion exchange capacity of membranes was used for monitoring coupling process between carbonyl of cinnamaldehyde and amine of chitosan. Results shown a dramatic decreased (from 5.11 to 2.73 meq/g) by increasing amount of cinnamaldehyde as a result of decreasing of amino groups along polymer backbone. Some physical characterization of membranes were measured and recorded which exhibited change in the polymer nature from hydrophilic to hydrophobic nature such as water uptake, moisture content and wettability. Electronic spectrum and color measurements show change in the membranes color from transparent to yellow with decreasing in the membranes transmission. Thermal analysis of prepared membranes (TGA and DSC) confirms the modification and show change of thermal stability of modified membranes. Mechanical analysis of membranes show breakdown of its mechanical properties due to disappearance of hydrogen bond of amine groups. Bio-evaluation of the fabricated membranes to be used as wound dressing membranes was investigated. In addition; Measuring of haemocomptability, thrombogenicity, biodegradability, blood clotting index and protein adsorption of such membranes were studied.
[M. S. Mohy Eldin, A. I. Hashem, A. M. Omer, T. M. Tamer (2015); Wound dressing membranes based on chitosan: Preparation, characterization and biomedical evaluation Int. J. of Adv. Res. 3 (Aug). 908-922] (ISSN 2320-5407). www.journalijar.com
