Synthesis of new N-arylhydrazone derivatives of 7- N-benzylamino-2-Oxo-2H-chromene-3- carbohydrazide using CuO nanocatalyst

A series of N-Arylhydrazone derivatives of N-benzylamino-2-Oxo-2H-chromene-3- carbohydrazide were synthesized. The ethyl-7-aminocoumarin-3-carboxylate used as appropriate starting material for synthesis of ethyl-N-benzylamino-2-Oxo-2H-chromene-3- carboxylate as the key intermediate by N-benzylation of amino group via nucleophilic substitution reaction. Reaction of the key intermediate ethyl-N-benzylamino-2-Oxo-2H-chromene-3- carboxylate with hydrazine hydrate yield the corresponding hydrazide derivative. The target compounds were synthesized by CuO nanoparticles catalyzed condensation of the hydrazide with the corresponding aromatic ketone/aldehydes and their structures were confirmed by IR and NMR techniques.