ANTHOCYANIN CONTENT, LIPID PEROXIDATION INHIBITION AND ANTI-SALMONELLOSIS ACTIVITY OF VITELARIAPARADOXAGAERTN AND PARKIABIGLOBOSA (JACQ.) BENTH BARK EXTRACTS

In a context where antimicrobial resistance limits the effectiveness of conventional treatments, the study of knowledge and practices related to anti-ulcer plants appears essential for exploring new the-rapeutic avenues of natural origin. The objective of this study is to determine the total anthocyanin content, the lipid peroxidation inhibition capacity and to evaluate the antimicrobial activity of Vitellariaparadoxa Gaertn. and Parkiabiglobosa (Jacq.) Benth stem bark extracts on salmonella strains. Salmonella spp isolated at the CNHU bacteriology unit from blood and stool samples. The results reported that total anthocyanins were only quantifiable in extracts of V. paradoxa bark, with high levels ranging from 31.17 , 17.13 to 66.79 , 8.34 mg/g of plant powder. Ethanolic extracts of V. paradoxa showed strong inhibition of lipid peroxidation (54.43-65.46%), significantly higher than that of P.biglobosa extracts (32.01-43.90%) and comparable or higher than that of ascorbic acid (38.56%), with the Vp50 and Vp97 extracts showing statistically higher activity than ascorbic acid. Sensitivity tests show that the vast majority of bacterial strains tested are highly sensitive to V. paradoxa and P. biglobosa bark extracts (85-95% and 90%, respectively), reflecting the strong overall antimicrobial activity of all extracts. MICs ranged from 3.125 mg/mL to 50 mg/mL, while MBCs ranged from 12.5 mg/mL to 50 mg/mL.