MECHANISTIC STUDY OF MELATONIN: A SYSTEMATIC REVIEW

  • Department of Physiology, Faculty of Basic Medical Sciences,College of Health Sciences, Usmanu Dan fodiyo University, Sokoto, Nigeria.
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Background: Melatonin, a neurohormone synthesized primarily in the pineal gland, plays a central role in regulating circadian rhythms and sleep-wake cycles.

Purpose: Beyond its chronobiotic functions,melatonin exhibits potent a ntioxidant,anti inflammatory, immunomodulatory,and oncostatic proper ties.This review explores the multifaceted molecular and cellular mecha nisms of melatonin across physiological and pathological conditions.

Methods: A systematic review following PRISMA guidelines was conducted using databases including PubMed, Scopus, Web of Science, and Google Scholar. Studies from 1990 to 2024 focusing on mechanisti c insights were included.

[B. Aliyu, N.S. Kangiwa and U.Z. Umar (2026); MECHANISTIC STUDY OF MELATONIN: A SYSTEMATIC REVIEW Int. J. of Adv. Res. (Jan). 1431-1433] (ISSN 2320-5407). www.journalijar.com

Aliyu Buhari
Usmanu Danfodiyo University, Sokoto, Nigeria
Nigeria

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