Effect of Human Leukocyte Antigen Compatibility on Renal Transplant Rejection in Kuwaiti patients
- Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura University, Egypt.
- Zoology Department, Faculty of Science, Tanta University, Egypt.
- Immunology and Organ Transplantation Departments, Hamad Al-Essa Organ Transplantation Center, Kuwait.
- Microbiology Department, Faculty of Medicine, Kuwait University, Kuwait.
- Immunology Department, Ministry of Health, Kuwait.
21 Downloads
62 Views
Abstract
Objective: The aim was to evaluate the possible effect of HLA-A, B and DR compatibility between patients and their donors on the development of rejection after renal transplantation in Kuwaiti population. Patients and Methods: HLA-A, -B, and –DR typing was performed by complement-dependent cytotoxicity method for 181 renal transplant patients and 181 donors. Results: No statistical significant differences were found between patients with rejection and those without for the frequencies of HLA antigens except for HLA-DR17 (OR=2.6, Pc=0.045). HLA incompatibility between patients and their donors was more associated with renal rejection when compared to HLA compatibility (P= 0.003). Also, gender mismatch was more frequent in patients suffering from rejection than patients without rejection (P=0.005) especially if a female patient received kidney from a male donor (P=0.008). Conclusion: HLA-DR17 antigen, HLA incompatibility between patients and their donors may be risk factors for the development of graft rejection after renal transplantation in Kuwaiti population.
Keywords
Article Analytics
How to Cite This Article
Youssef M. Mosaad, Merveet Mansour, Ibrahim Al-Muzairai, Turky Al-Otabi, Mohamed Abdul-Moneam, Rajaa Al-Attyiah, Manal Shahin (2015); Effect of Human Leukocyte Antigen Compatibility on Renal Transplant Rejection in Kuwaiti patients , Int. J. of Adv. Res., 3 (08), 846-855, ISSN 2320-5407.
Corresponding Author
This work is licensed under a Creative Commons Attribution 4.0 International License.