BURNING MOUTH SYNDROME AND ITS ASSOCIATEDSALIVARY BIOMARKERS

Burning Mouth Syndrome (BMS) is a chronic oral pain condition characterized by a persistent burning sensation of the oral mucosa in the absence of visible clinical abnormalities. It predominantly affects middle-aged and postmenopausal women and has a considerable negative impact on quality of life. The etiology is multifactorial, involving neuropathic, hormonal, psychological, and local contributing factors. Recent studies have highlighted the significance of salivary biomarkers in elucidating the underlying mechanisms of the disorder. Saliva serves as a non invasive diagnostic medium containing hormones, enzymes, cytokines, and oxidative stress markers that reflect both systemic and local alterations. Changes in salivary composition in individuals with BMS provide insights into disease pathogenesis and hold promise for diagnostic and therapeutic applications. This review presents an overview of Burning Mouth Syndrome with particular emphasis on the diagnostic and clinical relevance of salivary biomarkers.