SEX-RELATED DIFFERENCES IN GOUT: A COMPARATIVE STUDY IN A MOROCCAN COHORT

Background:The aim of this study was to characterize sex-related differences in the clinical, biological, and therapeutic features of gout in a Moroccan cohort. Methods:We conducted a cross-sectional study including 147 patients with gout (92 men and 55 women).Epidemiological, clinical, biological radiological, and therapeutic characteristics were analyzed and compared according to sex. Results:Compared with men, women with gout were older (64.9 vs. 60.85 years) and had a higher prevalence of cardiometabolic comorbidities, particularly hypertension and diabetes (p < 0.05). Renal involvement was significantly more frequent and more severe in women (p = 0.003). In contrast, men exhibited a more inflammatory and severe disease profile, with higher pain scores and elevated C-reactive protein levels (p = 0.003), as well as a higher frequency of tophi and more frequent structural joint damage. No significant differences were observed regarding monoarticular versus polyarticular presentation. Treatment patterns were broadly similar between sexes, although colchicine use was significantly more frequent in men (p = 0.001).