Regulatory Mechanisms of Bone Development and Function

Bone is metabolically active organ where 10% of it is normally and constantly replaced comprising two types of cells, osteoblasts (the bone forming cells) and osteoclasts (the bone-resorbing cells). These two cells are involved in a vital process called, bone remodeling. Bone remodeling is a dynamic, lifelong process in which old bone is removed from the skeleton and new bone is added. A variety of biochemical assays that reflect the activity of osteoblasts and osteoclasts have been developed for clinical use. They have helped increase our understanding of the bone remodeling cycle the pathogenesis of skeletal disorders, and the response of these disorders to therapy. However some regulatory mechanisms are working in order to maintain healthy bone on different levels. Summarizing that bone holds an outstanding and striking intrinsic capacity to regenerate.