THE IMPACT OF VACCINATION ON THE DYNAMICS OF PARATUBERCULOSIS TRANSMISSION IN GUINEA

Paratuberculosis, a chronic infectious disease that primarily affects ruminants, poses a major health and economic challenge for livestock systems in many developing countries,particularly in Guinea. This study analyzes the impact of vaccination on the transmission dynamics of this disease within herds, using a mathematical modeling approach inspired by epidemiological tools.A compartmental model adapted to paratuberculosis is formulated to describe the evolution of susceptible, infected, and vaccinated animal populations. The basic reproductionnumber, denoted R_0, is determined for the model without intervention, then compared to an effective reproduction number R0^V that incorporates vaccination coverage and vaccine efficacy.The results show that vaccination leads to a significant reduction in the diseases transmission potential, reflected in a decrease fromR_0 to R0^V. The analysis highlights the existence of a critical vaccination threshold beyond which the disease can no longer be sustained in theanimal population. However, the effectiveness of this strategy depends heavily on the level of vaccination coverage, husbandry conditions, and local epidemiological parameters.