ASSOCIATION BETWEEN PARAOXONASE 1 ALLELIC FREQUENCY DISTRIBUTION, CRUDE ODDS RATIOS, AND THE RISK OF CARDIOVASCULAR DISEASES IN A MOROCCAN POPULATION

  • Laboratoire des Sciences Agronomiques et Biologiques Appliquees (LaSABA), Faculte des Sciences et Techniques, Universite de Kara, Kara, Togo
  • Laboratoire de Biochimie, Institut Pasteur du Maroc.1, place Louis Pasteur, Casablanca, Maroc.
  • Laboratoire de Biologie et Sante, Unite Associee au CNRST-URAC-34 Universite Hassan- II-Mohammedia Casablanca, Faculte des Sciences Ben M’Sik, Casablanca, Maroc.
  • Depratement of medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke (QC), Canada.
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Aim : Paraoxonase 1 (PON1) an antioxidant enzyme associated with high density lipoprotein (HDL) is expressed in the Islet of Langerhans and may play a protective role against oxidative stress. This study investigated the relationship between the PON1 phenotype, allelic frequency distribution and the risk of cardiovascular disease complications. Methods : Three hundred subjects aged between 40-80 years including healthy controls, diabetic patients, and chronic renal failure/hemodialysis patients, were enrolled and divided into three groups of 100 subjects each. Participants were further stratified by age into middle-aged 40-59 years, (n=147), and elderly subjects 60-79 years (n = 153). Plasma malondialdehyde levels were measured by HPLC using thiobarbituric acid (TBA) derivatization with fluorescence detection. Vitamin E (α-tocopherol) concentration was determined by HPLC with electrochemical detection.

Nagba Yendoube Gbandjaba et, al (2026); ASSOCIATION BETWEEN PARAOXONASE 1 ALLELIC FREQUENCY DISTRIBUTION, CRUDE ODDS RATIOS, AND THE RISK OF CARDIOVASCULAR DISEASES IN A MOROCCAN POPULATION, Int. J. of Adv. Res., 14 (05), 1701-1712, ISSN 2320-5407. DOI URL: https://dx.doi.org/

Nagba Yendoube Gbandjaba
Laboratoire des Sciences Agronomiques et Biologiques Appliquees (LaSABA), Faculte des Sciences et Techniques, Universite de Kara, Kara, Togo .
Togo

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