Protective and curative role of allyl isothiocyanate against bladder carcinogenesis in rats

Study's background and aim: Allyl isothiocyanate (AITC) occurs in many cruciferous vegetables such as broccoli, cabbage, cauliflower. They showed chemopreventive activity against different tumors. Our objective is determination of protective effect and cure effect of AITC against bladder cancer (BC) in rats. Materials and methods: Sixty male Fischer rats were used for this study. Rats were randomized into six groups. At the end of the study period, blood samples were collected for biochemical analysis and the bladder tissues were removed for biochemical measurement and P53 gene expression. Results: There was no incidence of bladder cancer in normal controls. Meanwhile, all rats in bladder cancer group developed cancer with percentage 100%. In the protective group (AITC+ BC), bladder cancer lesions were seen in 60% of animals. In the curative group (BC+AITC), ten weeks of treatment with AITC 80% of rats were developed bladder cancer lesions. The size of bladder tumor was decreased and only small carcinomas are found. Conclusion: AITC has an efficient anticancer activity. It could protecting 40% of animals and suppressed all stages of the neoplastic processes.