COMPARATIVE EFFICACY AND SAFETY OF INTRAMUSCULAR CAMYLOFINDIHYDROCHLORIDE VERSUS INTRAVENOUS VALETHAMATE BROMIDE ON CERVICAL DILATATION IN THE ACTIVE PHASE OF LABOUR: A HOSPITAL-BASED CROSS-SECTIONAL STUDY

Background: Labour dystocia due to inadequate cervical dilatation is a major contributor to prolonged labour and operative delivery. Camylofin Dihydrochloride and Valethamate Bromide are widely used cervical antispasmodics, but comparative evidence on their efficacy and safety remains limited from central India. Methods: A hospital-based cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, between March 2024 and February 2026. Four hundred parturients with singleton term pregnancy in the active phase of labour (cervical dilatation > 4 cm) were allocated by closed-envelope randomisation to receive a single intramuscular dose of Camylofin Dihydrochloride 25 mg (Group A, n = 200) or intravenous Valethamate Bromide 8 mg, up to three half-hourly doses (Group B, n = 200). The primary outcome was the rate of cervical dilatation (cm/hr); secondary outcomes included duration of labour, mode of delivery, blood loss, APGAR score, NICU admission, maternal side effects, labour complications and pain perception (VAS).