Expression of cyclin D1 in breast carcinoma and its relation to other prognostic markers in Saudi female patients
- Department of Pathology and Cytopathology ,College of Medicine ,Taif University Laboratory and Blood Bank, King Abdul Aziz Hospital, Taif , KSA.
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Cyclin D1 expression has been implicated in breast cancer pathogenesis with prognostic impact which still controversial. We aimed to examine the frequency of cyclin D1 expression and to find the relationship between its expression and some well-known clinicopathologic prognostic determinants in breast invasive ductal carcinoma in Saudi females. This study included 100 cases of invasive ductal carcinoma. Immunohistochemistry was performed for estrogen receptors (ER), progesterone receptors (PR), Her2/neu and cyclin D1. Cyclin D1 expression was assessed and compared to the tumor histological grade, nodal status, tumor size and ER, PR, Her2/neu immunostaining results. Cyclin D1 was positive in 68%, and negative in 32%. There was a statistically significant reverse relationship between cyclin D1 and tumor grade. A statistically significant association between cyclin D1 expression and ER and PR. Our data strengthen the importance of cyclin D1 measurement in invasive duct carcinoma and its strong association with estrogen and progesterone receptor status.
[Dalal M. Nemenqani (2015); Expression of cyclin D1 in breast carcinoma and its relation to other prognostic markers in Saudi female patients Int. J. of Adv. Res. 3 (Sep). 990-996] (ISSN 2320-5407). www.journalijar.com
