Serum levels of Pregnancy Associated Plasma Protein -A , Activin-A and Inhibin-A in patients with ectopic pregnancy
- Department of Biochemistry, J.L.N.Medical College,Ajmer,Rajasthan,India.
- Department of Biochemistry, RUHS Associated Medical College, Jaipur, Rajasthan, India.
- NWR, Hospital, Ajmer,Rajasthan,India.
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Background: Serum Pregnancy Associated Plasma Protein -A (PAPP-A), Activin-A and Inhibin-A are markers related to embryo . The purpose of this study was to evaluate the serum level of PAPP-A ,Activin-A and Inhibin-A in early diagnosis of ectopic pregnancy. Materials and Methods: Serum levels of PAPP-A ,Activin-A and Inhibin-A were measured by Enzyme linked Immuno Sorbent Assay (ELISA) technique in 100 symptomatic women with ectopic pregnancy and 100 women with normal intrauterine pregnancy in the wards of Rajkiya mahila Chikitsalya, J.L.N. Medical College and Associated Group of Hospitals, Ajmer, after taking approval from ethical committee. These values were compared by T test. Results: The mean serum levels of PAPP-A, Activin-A and Inhibin-A in patients with ectopic pregnancy (0.49±0.10 µg/ml, 0.13 ± 0.04 ng/ml and 13.08±5.50 pg/ml) were significantly lower than in women with normal intrauterine pregnancy (1.33±0.12 µg/ml, 0.65±0.22 ng/ml and 1.99±50.60 pg/ml, respectively) (p<0.001). Conclusions: In this study single measurement of serum Activin- A may identify patients at risk of Ectopic pregnancy (EP) with a high sensitivity(100%) and specificity (99%).
Asha Makwana, Nagraj Soni, GG Kaushik, Sonali Sharma, Dheeraj Makwana (2015); Serum levels of Pregnancy Associated Plasma Protein -A , Activin-A and Inhibin-A in patients with ectopic pregnancy, Int. J. of Adv. Res., 3 (10), 188-191, ISSN 2320-5407. DOI URL: https://dx.doi.org/
