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Increased serum uric acid is known to be a major risk related to the development of several oxidative stress diseases. The aim of this study was to investigate the effect of crude flavonoids of Ginger (Zingiber officinale ) extract on serum uric acid levels, xanthine oxidase (XO) activity and oxidative stress biomarkers in normal and oxonate-induced hyperuricemic rats. A total of 60 male Wistar rats were randomly divided into ten equal groups; including 5 normal groups (vehicle, flavonoids low dose, flavonoids medium dose, flavonoids high dose and allopurinol) and 5 hyperuricemic groups (vehicle, flavonoids low dose, flavonoids medium dose, flavonoids high dose and allopurinol). Flavonoids fraction at three different concentration (50.100 and 250µg/kg.b.w) and allopurinol (5mg/kg.b.w) administrated to the corresponding groups by oral gavages once a day for 4 weeks. The results showed that Ginger' s flavonoids constituents did not cause any significant reduction in the serum uric acid levels and xanthine oxidas activity in normal rats, but significantly reduced the serum uric acid levels and the enzyme activity of hyperuricemic rats in a time-dependent manner. Flavonoids treatment led also to a significant increase in total antioxidant capacity and decrease in malondialdehyde concentration in hyperuricemic rats. Although the hypouricemic effect of allopurinol was much higher than that of flavonoids as a possible alternative for allopurinol, or at least in combination therapy, it could not significantly change oxidative stress biomarkers more than Ginger' s flavonoids. These features of flavonoids make them to minimize the side effects of allopurinol to treat hyperuricaemia and oxidative stress diseases.
[Hassan F. Al-Azzawie and Samah A.Abd (2015); Effects of Crude Flavonoids from Ginger ( Zingiber officinale), on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Xanthine Oxidase Activity in Oxonate-Induced Hyperuricemic Rats Int. J. of Adv. Res. 3 (Oct). 1033-1039] (ISSN 2320-5407). www.journalijar.com
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