Biochemical findings on cisplatin-induced oxidative neurotoxicity in rats
- Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
- Department of Biochemistry, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt.
- Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
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Cisplatin is an important chemotherapeutic agent used for the treatment of several cancers. However, various side effects such as neurotoxicity, nephrotoxicity, hepatotoxicity and ototoxicity restricted its usage for cancer treatment. Neurotoxicity is a clinically evident in patients that have undergone a full course of chemotherapy. Cisplatin forms DNA adducts that trigger cell death and production of reactive oxygen species inducing apoptosis. In this study, we examined our results for the first time suggesting combining cisplatin with curcumin as a combination therapy for protection and reducing side effects associated with cisplatin. Curcumin is a naturally occurring phenolic compound isolated from turmeric (Curcuma longa). It has antioxidant and anticarcinogenic effects. Male Wistar albino rats were allocated into four groups as follow; group I (control negative), group II (curcumin group), group III (cisplatin group), group IV (curcumin + cisplatin group). Antioxidant enzymes such as catalase and reduced glutathione were non-significantly decreased in the brain tissues of rats in cisplatin treated group and were significantly increased by pretreatment with curcumin. Also both of nitic oxide (NO) and lipid peroxidation levels were significantly increased in cisplatin treated groups and significantly decreased in groups which pretreated with curcumin.
[Reem M. Hashem, Ghada M. Safwat, Laila A. Rashed, Safaa Bakry (2015); Biochemical findings on cisplatin-induced oxidative neurotoxicity in rats Int. J. of Adv. Res. 3 (Oct). 1222-1231] (ISSN 2320-5407). www.journalijar.com
