The Effect of Turmeric and Ginger on Oxidative Modulation in end stage renal disease (ESRD) Patients

Background: End-stage renal disease (ESRD) is a state of oxidative stress (OS) due to uremic oxidant mediator’s accumulation, Various herbs are recognized as sources of natural antioxidants and thus play an important role in the chemoprevention of diseases resulting from lipid peroxidation. This study aim to investigate the effect of Turmeric and Ginger on oxidative modulation in chronic renal failure (ESRD) Patients. Methodology: Forty-five ESRD Patients were randomly assigned into 3 groups, group 1: control placebo group received starch, group 2: received turmeric and group 3: received ginger for 8 weeks. Plasma malondialdehyde (MDA), red blood cell (RBC) antioxidant enzyme activities including glutathione peroxidase (GPX), glutathione reductase (GR), and catalase (CAT), Plasma total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglyceride, albumin, and hemoglobin were also measured before and after study. Results: MDA level was significantly reduced (P<0.05) in both turmeric and ginger groups after trial and as compared with the control group, the ratio of decrease was significantly higher in the turmeric group. The enzyme activity of GPX, and CAT in RBCs were significantly increased (p<0.05) in both turmeric and ginger groups after trial and as compared with the control group. Conclusion: Regular ingestion of turmeric and ginger reduce plasma MDA and increases RBC GPX, and CAT activity in CRF patients.