Synthesis of a new class of 4-pyrazole substituted 1,4-dihydropyridines by multicomponent reactions

  • Department of Chemistry, A.V.V.M. Sri Pushpam College, Poondi -613 503 India.
  • Govt. Hr.Sec.School, Uranthairayankudikadu, Thanjavur Dt. 614 625 India.
  • Organic Chemistry Division, CLRI, Adayar, Chennai – 600 020 India.
  • Department of Chemistry, Periyar EVR College, Tiruchirappalli-620 023 India.
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1,4-Dihydropyridines (DHPs) are synthesized by the Hantszch method, which involves cyclocondensation of aldehyde, ?-ketoester and ammonia either in acetic acid at room temperature or refluxing in alcohol. Here we developed a one pot synthesize of a new class of 1,4 -dihydropyridine derivatives from cyclocondensation of pyrazole aldehyde, acetylacetone and ammonium acetate in acetic acid at room temperature.

Manickam. Pramesh, Selvaraj. Jayanthi, Paramasivam. T. Perumal and Bathey. R. Venkatraman (2015); Synthesis of a new class of 4-pyrazole substituted 1,4-dihydropyridines by multicomponent reactions, Int. J. of Adv. Res., 3 (11), 1094-1100, ISSN 2320-5407. DOI URL: https://dx.doi.org/

Manickam.Pramesh

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