Gonadotropin Releasing Hormone antagonist attenuates antidepressant-like effect of fluoxetine in mice against CRF-induced depression

The present study was designed to study the influence of gonadotropin releasing hormone (GnRH) receptor antagonist (antide) on antidepressant-like effect of fluoxetine in mice in which depression like effect was induced by i.c.v. administered corticotrophin releasing factor (CRF), and assessed by using forced swim test. CRF (0.1 and 0.3 nmol/mouse) administration increased immobility time indicating depression-like effect, and 15 min prior treatment with fluoxetine (10 and 15 mg/kg, s.c.) was found to attenuate the same. However, this attenuation by fluoxetine pre treatment was not evident in a group which received GnRH antagonist – antide (10 nmol/mouse, i.c.v.) 10 min prior to fluoxetine. These observations point towards the possible role of GnRH in antidepressant –like effect of fluoxetine.