Correlation between Serum Cytokines Level (IL-6 , IL-10 , TNF-? and MIF ) of Urinary Bladder Carcinoma Patients

Bladder cancer is abnormal cells multiply without control in the bladder arising from the epithelial lining (the urothelium) of the urinary bladder has the highest recurrence rate of any malignancy. Rarely the bladder is involved by non-epithelial cancers, such as lymphoma or sarcoma. Bladder cancer generates the highest medical cost per patient and it is the fifth most expensive cancer in terms of total medical care expenditures. Cytokines represent a large family of proteins molecules that have a broad range of functions produced by more than one type of cell. cytokines signaling are thought to be contribute in bladder tumor environment via two mechanism: stimulation of cell growth and inhibition apoptosis of damaged cells. The aim of our study was to estimate serum level of (IL-6,IL-10,TNF-? and MIF)before TURBT surgery. Blood have been obtained from 135 subjects which divided into three groups (UBC, UBD an healthy control )then measured the serum level of four cytokines by Sandwich ELISA .Results showed that all cytokines expressed high serum level in UBC group than UBD and healthy group with significant difference . The highest level of cytokines strongly associated with advanced stage characterized by high grade.