Evaluation of some stress indicators and their relation with leptin injection in experimentally induced diabetic rats.
- College of Biotechnology, Al-Qadisiya University, Iraq.
- College Of Pharmacy, Al-Qadisiya University, Iraq.
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The aim of this study was to investigate the effects of exogenous leptin administration on some stress indicators in streptozotocin (STZ)-induced diabetes rats.In this study wistar albino rats were divided into two main groups (first was 5 day, and second was 10 day), each one subdivided into four groups (5 rat per subgroup): 1. Control, 2. Leptin (10 μg/kg leptin, sc. daily), 3. Diabetes, (induced by single injection of streptoztocin (65 mg/kg bw)) 4. Leptin + diabetes. At the end of the experiments the blood collected by cardiac puncture under anesthesia. Plasma catalase, glutathione, malondialdehyde, and IL-6 levels were measured. Our results showed that diabetes decrease glutathione and catalase levels and increase MDA and IL-6 levels, while leptin treatment reverse these changes.
[Shaymaa Rabeea Madhkhoor and Ihsan Raisan Ibrahim. (2016); Evaluation of some stress indicators and their relation with leptin injection in experimentally induced diabetic rats. Int. J. of Adv. Res. 4 (Apr). 9-13] (ISSN 2320-5407). www.journalijar.com
