Formulation and Evaluation of Novel Oral System (Chewing Gum) of Domperidone

Oral Delivery Systems have proven through time as best kind of approach for delivering various drugs. But certain drugs given by oral route undergo extensive First pass metabolism which leads to low bioavailability, making them less effective. To overcome this Novel Oral Drug Delivery Systems, i.e., Chewing Gums were developed as an alternate for conventional oral systems. These were used for both systemic and local delivery of drugs. These systems have advantages like increased patient compliance, increased Bioavailability and self administration. Domperidone, an anti emetic drug was given in the form of chewing gums in this study. As this drug is poorly water soluble, to enhance its solubility, solubilizers were used in various ratios. For the obtained formulations, evaluation studies were carried out. Weight variation, Drug content values were found to be within standard limits prescribed. In vitro studies were carried out using modified disintegration apparatus and all the formulations showed release between 70-90%. Ex vivo studies were carried out using porcein buccal mucosa and up to 60% of drug release was found. Drug excipient compatibility was studied by FTIR studies. ANOVA was performed to determine significance between formulations.