Basosquamous carcinoma (BSC) in old Iraqi patient treated with 25% topical podophyllin solution

Background: Basosquamous carcinoma (BSC) is subtype of BCC reported to constitute approximately 0.4 to 12% of all basal cell carcinoma (BCC). (1) It has also been called basaloid squamous carcinoma, and metatypical BCC. (2) The term BSC should be used only to define lesions that bear both typical histopathological features of BCC and SCC in conjunction with a transitional zone. BSC is reported to have a higher prevalence of metastasis even higher than SCCs (3). Podophyllin is an antimitotic and caustic agent. Objective: to test the effectiveness of topical 25% podophyllin solution in treatment of BSC. Methodology and results: 70 years old male, Farmer, skin type 4, Baghdad' presented with indurate keratotic lesion on mid the nose for 6 months duration treated with topical podophyllin solution (25%) weekly for six weeks. Conclusion: Topical 25% podophyllin solution is effective in treatment of Basosquamus cell carcinoma and some types of basal cell carcinoma, with good cosmetic result.