Difficult Thyroid Histopathology in Nodular Goitre: A Diagnostic Dilemma- Case series of two cases.

Fine needle aspiration cytology (FNAC) is a rapid, inexpensive procedure which is also highly sensitive and specific in categorization of thyroid lesions. Although,there is a large body of world literature claiming possible limitations and pitfalls of this procedure. Various types of histological alterations are seen in thyroid tissue, due to trauma caused by the aspiration needle in FNAC. These include acute changes such as hemorrhage, granulation tissue, mitosis, capsular distortion (pseudoinvasion) & infarction, and chronic alterations such as fibrosis, metaplasia, infarction, cyst formation, papillary degeneration, papillary endothelial proliferation and calcification. This case report describes two cases of Colloid goitre with difficult and unusual histopathological features causing confusion in diagnostic confirmation. Therefore, a thorough knowledge of possible FNAC related alterations is essential for correct diagnosis and opting appropriate treatment to avoid misdiagnosis.