Antioxidant Activity of Erythrina variegata and Breynia vitis-idaea in Alloxan Induced Diabetic Rats

The present work was carried out to study the effect of roots of Erythrina variegata and leaves of Breynia vitis-idaea on antioxidant enzymes levels in Alloxan induced diabetic rats. Alloxan (120 mg/kg, i.p) induced diabetic rats were treated with alcohol and aqueous extract at a dose levels of 300 and 600 mg/kg for 21 days. Antioxidant enzymes levels viz. Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured in liver homogenate. After 21 days of experimental period the level of reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) significantly increase, while elevated level of lipid peroxidation (LPO) significantly decrease. It suggests that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats. So, it can be concluded that both the extracts of Erythrina variegata and Breynia vitis-idaea are very promising candidate for the design of new drugs based on its pharmacological effects of antioxidant adequacy.