SYNTHESIS AND EVALUATION OF NOVEL COUMARINYL THIAZOLE AZODYES AS ANTI-BACTERIAL AND ANALGESIC

Coumarin ring has an easy accessibility in the biological systems and has varied useful medicinal properties. Among the wide range of 5-membered heterocycles explored to develop pharmaceutically important molecules, thiazoles have played a pivotal role in medicinal chemistry. Azo compounds play a prominent role in almost every type of application. Keeping this importance in view, in the present work, novel azo compounds of 3-(2-Amino-1,3-thiazole-4-yl)-2H-chromen-2-one and phenols & anilines (4a-4h) were synthesized by multistep procedure which involved the formation of 3-Acetyl coumarin(1) by Knoevenagel condensation, its bromination and then cyclization using thiourea and sodium acetate resulting in 3-(2-Amino-1,3-thiazole-4-yl)-2H-chromen-2-one(3). This was then diazotized and coupled with various phenols & anilines to yield the targeted diazocompounds (4a-4h). Finally they were evaluated for their analgesic and antimicrobial potency.