PROTECTIVE EFFECT OF SOLANUM NIGRUM ON NEPHROTOXICITY IN ANIMALS TREATED WITH ANTITUMOR DRUG (CISPLATIN).
- Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Menoufia, Egypt.
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Objectives. The aim of this study is to evaluate the effect of Solanum nigrum on nephrotoxicity and oxidative stress induced by cisplatin. Methods. Male mice were divided into 4 groups: control (Group A), cisplatin (Group B), Solanum nigrum (Group C), and cisplatin plus Solanum nigrum (Group D). Creatinine and urea were evaluated for nephrotoxicity. Catalase (CAT), glutathione-S-transferase (GST), nitric oxide (NO), and malondialdehyde (MDA) were measured colorimetrically and heme oxygenase-1 (HO-1) was determined by real-time PCR for evaluation of oxidative stress. Results. CAT significantly decreased while creatinine, urea, GST, NO, MDA, and HO-1 significantly increased only in cisplatin-treated group. Discussion. Solanum nigrum ameliorates nephrotoxicity and oxidative stress induced by cisplatin.
Ayatullah Mohamed Salama, Khalid Bassiouny, Ibrahim Helmy El-Sayed and Mahmoud Emam Nasr. (2016); PROTECTIVE EFFECT OF SOLANUM NIGRUM ON NEPHROTOXICITY IN ANIMALS TREATED WITH ANTITUMOR DRUG (CISPLATIN)., Int. J. of Adv. Res., 4 (02), 1013-1019, ISSN 2320-5407. DOI URL: https://dx.doi.org/
