Identification and synthesis of process related unspecified impurities of betahistine dihydrochloride.
Nagender Rao D
, Reguri Buchi Reddy
, Mukkanti K
, Joseph Prabahar K
, Thanasekaran Ponpandian
, Venu Konda
, Purandhar Koilkonda
and Seshagiri Rao M
- Inogent Laboratories Private Limited, Department of Research & Development, 28A, IDA, Nacharam, Hyderabad 500 076, India.
- Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 072, India.
- IPCA Laboratories Ltd, Chemical Research and Development, Plot- 123AB, Charkop, kandivali industrial Area, Kandivali (West), Mumabi 400 067, India.
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Herein, we describe the syntheses and characterization of process related impurities of anti-vertigo drug betahistine dihydrochloride. We have identified seven impurities during the synthesis of betahistine dihydrochloride from 2-pyridineethanol. Among that, four impurities such as N-acetyl betahistine, 2-(pyridine-2-yl)ethyl acetate, N-methyl betahistine and N-methyl-2-(pyridine-2-yl)prop-2-en-1-amine are not reported in the literature. In this article, we describe the origin, syntheses and characterization of three of these unspecified impurities.
Nagender Rao D, Reguri Buchi Reddy, Mukkanti K, Joseph Prabahar K, Thanasekaran Ponpandian, Venu Konda, Purandhar Koilkonda and Seshagiri Rao M (2016); Identification and synthesis of process related unspecified impurities of betahistine dihydrochloride., Int. J. of Adv. Res., 4 (03), 842-848, ISSN 2320-5407. DOI URL: https://dx.doi.org/
