A TRITERPENOID SAPONIN FROM THE ROOT BARK EXTRACT OF Massularia acuminata spp.
- Chemistry Programme, Abubakar Tafawa Balewa University, Bauchi, Nigeria.
- Department of Science Laboratory Technology, Federal Polytechnic, Damaturu, Nigeria.
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Compound CFME2 was isolated as the second column fraction of chloroform soluble fraction of methanol extract of the root bark of Massularia acuminata and was identified to be a bioactive triterpenoid saponin. On the basis of chemical and spectroscopic analyses, the structure of the compound was established and the compound identified as 3-O – ?- D- glucopyranosyl – (1-4)- ?- D- glucopyranosyl – (1-4)- ?- D- glucopyranosyl – 28- O – ?- D- glucopyranosyl – (1-4)- ?- D- glucopyranosyl – (1-4)- ?- D- glucopyranosyl- oleanolic acid. 1D- and 2D- NMR experiments which include 1H, 13C, DEPT, 1H-1H COSY, HSQC and HMBC were used to achieve the structural elucidation. The compound showed good inhibitory ability against the microorganisms, Salmonella spp, Staphylococcus aureus, Escherichia coli, Aspergillus niger and Candida albicans.
[Harami M. Adamu, Uduak S. Ukekpe and Eno O. Ekanem (2016); A TRITERPENOID SAPONIN FROM THE ROOT BARK EXTRACT OF Massularia acuminata spp. Int. J. of Adv. Res. 4 (Mar). 1400-1406] (ISSN 2320-5407). www.journalijar.com
