EVALUATION OF MUTATION OF BAX SNPS WITH RISK OF SQUAMOUS CELL CARCINOMA HEAD AND NECK (HNSCC) IN KASHMIRI POPULATION.

Objective: To find relationship between Bax SNPs and squamous cell carcinoma head and neck (SCCHN) in patients from Kashmir Study design: Case control study. Setting: Tertiary care hospital (SMHS associated Medical College, Srinagar, Kashmir, India) Participants: 50 cases and 50 controls of squamous cell carcinoma head and neck reported our hospital from 2013-2016. Results: In the present study no evidence of associations between BAX (-248 G>A) and squamous cell carcinoma head and neck , further analyses showed that among BAX heterozygotes after adjustment for age, sex, and smoking status, the BAX GC ( Arg-Pro) genotype was associated with an elevated risk of SCCHN [OR=1.354, 95% CI= 0.8629-2.124 )compared with the BAX GG genotype and OR=1.962, 95% CI=0.9129-2.465) compared with the combined genotypes (GG+CC)],. Our data suggest that the risk of SCCHN may be associated with these SNPs of BAX. Larger studies are needed to validate these findings.