ROLE OF PREVIOUSROTAVIRUS INFECTION AND ITS ASSOCIATION WITH IFN-? IN OCCURRENCE OF CELIAC DISEASE IN IRAQI PATIENTS.

Celiac disease(CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals, many environmental triggering factors are suggested to participate in its pathogenesis, Several studies were struggled to establish the association between some microbial infections and CD development, some of these studies were suggested an association between rotavirus infections and CD development, but this association still unconfirmed yet, so that, this study aims to evaluate the role of previousrotavirusinfections and its association with IFN-? in occurrence of celiac disease.Sample of 80 Iraqi celiac patients has been chosen from all suspected patients who attending to Al-Suder- Medical city during the period of April 2015 to November 2015, also 80 healthy individuals (control) were included in this study, all patients were undergo blood investigations for anti- rotavirus IgG ,AGA-IgA, AGA-IgG, tTG-IgA , tTG-IgG and IFN-? tests. Results showeda significant decrease in levels of anti-rotavirus IgG in celiac patients compared to healthy group ,p <0.05, and a significant increasing in levels of IFN-? in celiac patients compared to healthy group ,p <0.05, also there is significant negative correlation between IFN-? and anti-rotavirus IgG in celiac patients, P < 0.01.Significant correlation between anti-rotavirus IgG and AGA-IgA,P< 0.01(P=0.004), also there is significant correlation between anti-rotavirus IgG and tTg-IgG,P< 0.01(P=0.007). In other hand ,there is no significant correlation between anti-rotavirus IgG and tTg-IgA, P > 0.01(P=0.702) and no significant correlation between anti-rotavirus IgG and AGA-IgG, P > 0.01(P=0.154).