ACETYLSALICYLIC ACID (ASA) IMPAIRS INFLUENZA B VIRUS PROPAGATION AND DELAY APOPTOSIS IN INOCULATED A549 AND MDCK II CELL LINES.

Despite the increasing knowledge in the influenza virus host interactions, most of the published work focuses on influenza A viruses, leaving a gap with respect to influenza B virus host interactions , Here we examined acetylsalicylic acid (ASA), also known as aspirin, on A549 and MDCKII cells infected by INF B Yamagata virus ,and the anti-NF-kB and anti-influenza virus action of ASA were studied ,our results show that a few millimolar concentration range from ASA which do not affect the viability of cultured cells, can impaired INF B virus propapagation and playing a role in delaying apoptosis via impaired TNF? induced NF-?B signaling.