Immunohistochemical Study of p53 and bcl-2 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Cancer of the oral cavity is one of the leading causes of death worldwide. Much of these cancers are squamous cell carcinoma of the oral lining mucosa. Epithelial dysplasia of oral mucosa have a high probability of developing into oral squamous cell carcinoma and the percentage of such progression is believed to be directly proportional to the severity of dysplatic changes. Many biomarkers have been studied in the past to define the genetic progression model for oral squamous cell carcinoma. The most frequently studied marker is a tumor suppressor gene p53 and its aberrant protein expression is a well documented event in the development of oral squamous cell carcinoma. The protein expression...