20Jan 2017


  • High institution for infertility diagnosis and ART, Al Nahrin University. Collage of Medicine, Al Nahrin University.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Maternal accommodation to normal pregnancy begins shortly after conception,during pregnancy the anatomical and histological changes occur in the kidneyas a maternal adaptation for physiological changes. Aim: Evaluation morphological changes in the kidney glomeruli and tubules during pregnancy, Histomorphometrical assessment of glomeruli and tubular changes with pregnancy. Material and Method: This study carried on 40 mature mice divided into two groups, 20 pregnant mice served as experimental group and 20 non-pregnant mice as a control group, kidneys were removed; the weight is measured and then fixed, dehydrated in ascending grades of alcohol, cleared in xylene and infiltrated with paraffin. The paraffin blocks were made and 5?m thin sections were obtained using a rotary microtome. The sections were stained with H&E stain, PAS examined under light microscope. Result: Under the light microscope, the kidney in experimental group show the many anatomical changes as increase in Wight, elongated and increase in width, and showed many histological changes as a glomerular enlargement with decrease of urinary space and dilation in proximal and distal tubule. A statistically significant differences have been shown in the diameter of renal corpuscle, glomerular tuft and Bowman’s space, and also in the renal tubules proximal and distal convoluted tubules (p<0.001). And in Wight, elongation and width as (p<0.001). Conclusion: The results of the present study indicated during pregnancy kidney undergo to anatomic change as increase in size and Wight, and histologic change as elongation in glomeruli, and dilation in diameter of tubule.

  1. Stephen N. Sturgiss, William Dunlop and John M. Davison. Renal hemodynamics and tubular function in human pregnancy.  Baillie’s clinical obstetrics and gynecology. 1994: 8(2). 209-232.
  2. Keinth L.Moori, Arthur F. Dalley and Anne M.R.Agur. Clinically oriented Anatomy. 6th edition. Philadelphia. wolters Kluwer;2010.
  3. Al-Samawy. E.M.R. Morphological and Histological study of the kidneys on the Albino rats, Al-Anbar Journal of Veterinary Sciences, 2012; 5(1).115-119.
  4. Weinstein M.A. A mathematical model of the rat nephron. American physiology Society.2015; 308(10): 1098-1118.
  5. Pollak R.M. et at. The Glomerulus: The Sphere of Influence. Clinical Journal of the American Society Nephrology. 2014; 9(8): 1461-1469.
  6. Ichimura Koichiro. Structural disorganization of pronephric glomerulus in rat. PubMed. 2012; 241(12): 1922-1923.
  7. Curthoys P. N. and Moe O.W. Proximal Tubule Function and Response to Acidosis. Clinical Journal of the American Society of Nephrology .2014; 9(9):1627-1638.
  8. Gross J.B, Imai M, and Kokko J. P. A functional comparison of the cortical collecting tubule and the distal convoluted tubule. The Journal of Clinical Investigation. 1975; 55(6): 1284-1294.
  9. Murlimanju B.V. et al. Morphometric Parameters of the Human Adult Kidney: An Anatomical Study. International Journal of Morphology. 2014; 32(2): 656- 659.
  10. Warui C. N. Light microscopic morphometry of the kidneys of fourteen avian species. Journal of anatomy. 1989; 162(1):19-31.
  11. Hussein Wael and Lafayette Richard A. Renal function in normal and disordered pregnancy. NIH Public Access. 2014; 23(1): 46- 53.
  12. Brown Mark A. Urinary tract dilatation in pregnancy. American journal of obstruct and gynecology.1990; 164(2): 641-643.
  13. Cheung Katharine L and Lafayette Richard A. Renal Physiology of Pregnancy. Advance Chronic Kidney Disease. 2013; 20(3): 209- 214.
  14. Bailey R. R. and Rollest G. L. Kidney length and ureteric dilation in the puerperium. The Journal of Obstetrics and Gynecology of the British. 1971; 78(1): 55-61.
  15. Moiler Jens Chr. Dimensional changes of proximal tubules and cortical capillaries in chronic obstructive renal disease. Virchows Arch A. 1986; 410(1):158-153.
  16. Jia L. Zhuo and Xiao C. Li. Proximal Nephron. HHS public access. 2014; 3(3): 1079-1123.
  17. Beck JC, Sacktor B. The sodium electrochemical potential-mediated uphill transport of D-glucose in renal brush border membrane vesicles. Journal of Biology and Chemistry. 1978; 253(1):5531–5535.
  18. Atherton J. C., and Green R. Renal tubular function in the gravid rat. Baillinre's Clinical journal of Obstetrics and Gynecology. 1994; 8(2):265-285.
  19. Atherton J. C., and Piriei Susan C. The effect of pregnancy on glomerular filtration rate and salt and water reabsorption in the rat. Journal of physiology. 1981; 319(1):153-164.
  20. Moiler Jens Chr. Dimensional changes of proximal tubules and cortical capillaries in chronic obstructive renal disease. Virchows Arch A. 1986; 410(1):158-153.
  21. Pa?asz Czekaj, et al. Morphological changes in lungs, placenta, liver and kidneys of pregnant rats exposed to cigarette smoke. International Arch Occupy Environ Health. 2002; 75(1):27-35.

[Asawer K.M. Al- fatlawee, May F.M. Al-Habib and Mohammad Oda Selman. (2017); HISTO-MORPHOMETRICAL STUDY ON KIDNEY GLOMERULI AND CORTICAL TUBULE IN LATE PREGNANCY. Int. J. of Adv. Res. 5 (Jan). 83-88] (ISSN 2320-5407). www.journalijar.com

Prof. Dr. Mohammad Oda Selman


Article DOI: 10.21474/IJAR01/2723      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2723