20Jan 2017

GENETIC POLYMORPHISM OF PARAOXONASE 3 GENE ALA99ALA IN ADJAANDMAHIETHNIC GROUPS IN BENIN.

  • Department of Human Biology Engineering, Research Laboratory of Applied Biology, Abomey-Calavi Polytechnic School, Abomey-CalaviUniversity , Republic of Benin. Department of Genetics and Biotechnologies, Faculty of Sciences and Techniques, Abomey-CalaviUniversity, Republic of Benin.
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Introduction:The paraoxonase has anti-atherogenic activity which may be altered by the coding gene polymorphisms. The purpose of this study was to assess the genotypic distribution and allelic frequencies in paraoxonase 3 gene Ala99Ala polymorphism in Beninese Adjaand Mahi ethnic groups. Materials and methods:The paraoxonase 3 gene Ala99Ala polymorphism of 144 subjects of Beninese AdjaandMahi ethnic groups was studied using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique and compared with that in Beninese Abomey-Calavipopulationand others world populations. Results:The alleles A and G frequencies were 67.0percent and 33.0 percent respectively ofAdjaethnic group; and 66.0 percent and 34.0percentrespectively ofMahi ethnic group. There were no significant ethnic differences for these allelic frequencies between these two ethnic groups. Conclusion:The genotypic distribution and allelic frequenciesof paraoxonase 3 gene Ala99Ala polymorphism in BenineseAdjaand Mahi ethnic groups were significantly different from those in BenineseAbomey-Calavipopulationand in others world populations respectively.

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[Julien A. G. Segbo, Chantale Houngnonvi, Antoine Abel Missihoun, Paulin Sedah and Clement Agbangla. (2017); GENETIC POLYMORPHISM OF PARAOXONASE 3 GENE ALA99ALA IN ADJAANDMAHIETHNIC GROUPS IN BENIN. Int. J. of Adv. Res. 5 (Jan). 467-471] (ISSN 2320-5407). www.journalijar.com

Dr Julien A. Gaetan

DOI:

Article DOI: 10.21474/IJAR01/2768      
DOI URL: http://dx.doi.org/10.21474/IJAR01/2768

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