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Locked nucleic acids (LNA) are a class of nucleic acid analogues in which the ribose ring is locked by a methylene bridge connecting the 2’-O atom and the 4’-C atom. Locked nucleic acids are modified RNA nucleotides that increase the thermal stability of oligonucleotides. Structurally, they are RNA mimics. Locked nucleic acids are very promising in the study of oligonucleotides, particularly in very specific fields like cancer.
[Archana Sharma, Gunjan Sharma (2014); Locked Nucleic Acid-A Cancer Therapeutic Agent Int. J. of Adv. Res. 2 (4). 0] (ISSN 2320-5407). www.journalijar.com
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